All drugs, or compounds that act like drugs, when administered orally, are
absorbed from the gastrointestinal tract into the portal venous circulation and
pass through the liver (first pass metabolism) where the process of drug
metabolism begins. Suppositories, like intravenous (IV), intramuscular (IM),
and transdermal methods of administration, bypass this “first pass” effect and
are absorbed into the lower and middle hemorroidal veins without
encountering liver metabolism. In addition, the rectum is filled with blood
vessels that offer direct access into the body’s bloodstream via the inferior
vena cava. This allows for rapid access to systemic circulation.
When nutrients are put into an active delivery system, called a suppository
base, and then placed in the rectum, a “transfer” of water from the rectum to
the fat-based suppository must occur for the separation of the active
ingredients from the base into the rectal mucosa. Biotox’s proprietary base is
formulated with key ingredients that not only protect the active ingredients but
also facilitate the movement of the active compounds from the base to the
rectum. This technology facilitates solubility, and allows a compound that is
usually insoluble in water (hydrophobic) to dissolve, and thus be absorbed.
This is crucial for poorly absorbed compounds.
Biotox suppositories are comfortable, non-irritating, rapid-melting, fully
absorbed in 15-20 minutes, and imperceptible after insertion.
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