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How do Rectal Suppositories Work?

All drugs, or compounds that act like drugs, when administered orally, are

absorbed from the gastrointestinal tract into the portal venous circulation and

pass through the liver (first pass metabolism) where the process of drug

metabolism begins. Suppositories, like intravenous (IV), intramuscular (IM),

and transdermal methods of administration, bypass this “first pass” effect and

are absorbed into the lower and middle hemorroidal veins without

encountering liver metabolism. In addition, the rectum is filled with blood

vessels that offer direct access into the body’s bloodstream via the inferior

vena cava. This allows for rapid access to systemic circulation.

When nutrients are put into an active delivery system, called a suppository

base, and then placed in the rectum, a “transfer” of water from the rectum to

the fat-based suppository must occur for the separation of the active

ingredients from the base into the rectal mucosa.  Biotox’s proprietary base is

formulated with key ingredients that not only protect the active ingredients but

also facilitate the movement of the active compounds from the base to the

rectum.  This technology facilitates solubility, and allows a compound that is

usually insoluble in water (hydrophobic) to dissolve, and thus be absorbed.

This is crucial for poorly absorbed compounds.

Biotox suppositories are comfortable, non-irritating, rapid-melting, fully

absorbed in 15-20 minutes, and imperceptible after insertion.

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